The declaration that the miracle had again taken place was made at the start of Mass by Abbot Vincenzo De Gregorio.
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The Archdiocese of Chicago serves approximately 2.2 million Catholics.
NEWS ANALYSIS: Pope Francis sparked a furor when he urged Chinese Catholics to be ‘good citizens,’ but experts say the Church, by its very nature, remains a thorn in the side of contemporary totalitarian regimes from China to Nicaragua.
St. John Paul II wrote in his 1994 apostolic letter Ordinatio Sacerdotalis that the ministerial priesthood is reserved only for men and that the Church has no power to change this.
Archbishop Lefebvre died in a state of excommunication in 1991 for consecrating four bishops without the approval of Pope John Paul II.
The letter was signed by Fabrizia Raguso and other former sisters of the Loyola Community, a Slovenian community co-founded by Father Rupnik and Sister Ivanka Hosta.
The museum and visitors center, which opens Sept. 22, tells the life story of Mother Seton through an immersive experience, examining her impact as the first native-born American to be canonized.